H2N2V1, Main, Exploration, bibRecord, 001871

Induction of immunological memory in baboons primed with DNA vaccine as neonates

Identifieur interne : 001871 ( Main/Exploration ); précédent : 001870; suivant : 001872

Induction of immunological memory in baboons primed with DNA vaccine as neonates

Auteurs : Adrian Bot [États-Unis] ; Michael Shearer [États-Unis] ; Simona Bot [États-Unis] ; Mary Avriette [États-Unis] ; Adolfo Garcia-Sastre [États-Unis] ; Gary White [États-Unis] ; Catherine Woods [États-Unis] ; Ronald Kennedy [États-Unis] ; Constantin Bona [États-Unis]

Source :

Vaccine [ 0264-410X ] ; 2001.

RBID : ISTEX:4B381DDFB753E79D602578367256015608B7D421

English descriptors

KwdEn :
- DNA vaccination, Influenza virus, Neonates, Primates.
Teeft :
- Antibody, Antibody response, Antibody responses, Antibody titers, Assay, Baboon, Baboons inoculated, Baboons vaccinated, Control baboons, Control plasmid, Elisa, Hemagglutination, Highest dose, Humoral, Igg1, Igg1 antibodies, Immune, Immune memory, Immunization, Immunol, Inoculated, Instillation, Maternal antibodies, Nasal, Nasal wash, Nasal washes, Neonatal, Neonatal stage, Neonate, Neutralizing antibodies, Newborn baboons, Newborn mice, Newborn primates, Pbmc, Plasmid, Primates, Respiratory tract, Secondary responses, Sigma, Titer, Vaccinated, Vaccinated baboons, Vaccination, Vaccine, Various intervals, Viral, Viral immunol, Virus, Virus challenge.

Abstract

Abstract: DNA immunization is a potential vaccination strategy for neonates and infants. We tested the ability of a prototype DNA vaccine against influenza virus to prime lasting immunity when administered to newborn non-human primates. Neonatal DNA vaccination triggered virus-specific and neutralizing antibodies of titers and persistence depending on the vaccine dose. Subsequent exposure to influenza virus, revealed significantly increased recall responses in the baboons vaccinated with DNA during the neonatal stage. The humoral and cellular responses were enhanced in the baboons primed with DNA vaccine as neonates. Thus, neonatal DNA vaccination of non-human primates triggered immune memory that persisted beyond infancy.

Url:

https://api.istex.fr/ark:/67375/6H6-JLMPVZ9H-H/fulltext.pdf

DOI: 10.1016/S0264-410X(00)00430-8

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: 000F80
to stream Istex, to step Curation: 000F80
to stream Istex, to step Checkpoint: 000698
to stream Main, to step Merge: 001911
to stream Main, to step Curation: 001871

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: DNA immunization is a potential vaccination strategy for neonates and infants. We tested the ability of a prototype DNA vaccine against influenza virus to prime lasting immunity when administered to newborn non-human primates. Neonatal DNA vaccination triggered virus-specific and neutralizing antibodies of titers and persistence depending on the vaccine dose. Subsequent exposure to influenza virus, revealed significantly increased recall responses in the baboons vaccinated with DNA during the neonatal stage. The humoral and cellular responses were enhanced in the baboons primed with DNA vaccine as neonates. Thus, neonatal DNA vaccination of non-human primates triggered immune memory that persisted beyond infancy.</div>
</front>
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<name sortKey="Avriette, Mary" sort="Avriette, Mary" uniqKey="Avriette M" first="Mary" last="Avriette">Mary Avriette</name>
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<name sortKey="Bot, Simona" sort="Bot, Simona" uniqKey="Bot S" first="Simona" last="Bot">Simona Bot</name>
<name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name>
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<name sortKey="Shearer, Michael" sort="Shearer, Michael" uniqKey="Shearer M" first="Michael" last="Shearer">Michael Shearer</name>
<name sortKey="White, Gary" sort="White, Gary" uniqKey="White G" first="Gary" last="White">Gary White</name>
<name sortKey="Woods, Catherine" sort="Woods, Catherine" uniqKey="Woods C" first="Catherine" last="Woods">Catherine Woods</name>
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Induction of immunological memory in baboons primed with DNA vaccine as neonates

Induction of immunological memory in baboons primed with DNA vaccine as neonates

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri